Parkinson’s disease is a progressive neurological disorder which results from a deterioration of neurons in the region of the brain that controls muscle movement. The degeneration creates a shortage of the neurotransmitter dopamine, causing the movement impairment, that characterize the disease.
People with Parkinson’s disease often experience trembling, muscle rigidity, difficulty walking, and problems with balance and coordination.
Although there are many theories about the cause of Parkinson’s, the etiology remains unexplained.
Various research papers have suggested mitochondrial abnormalities, environmental neurotoxic exposures, selective generation of potential toxins or reduced detoxification capacity. Infectious agents and genetic factors are also possible reasons for the disease.
Biochemical changes including increased levels of neurotoxic metals, the inhibition of mitochondrial complex 1 activity, and depleted glutathione levels occurring in the substantia nigra, all suggest that oxidative stress is present and pathologically involved in Parkinson’s disease.
Studies have also highlighted glutathione deficiency may be a common factor in parkinson’s with nigral damage.
Glutathione exhibits several functions in the brain by acting as an antioxidant and a redox regulator. Glutathione depletion affects mitochondrial function via the selective inhibition of mitochondrial complex 1 activity. Oxidative damage due to glutathione depletion may also encourage aggregation of defective proteins leading to cell death of nigral-striatial dopaminergic neurons.
Studies have begun to validate the hypothesis that the dysfunction of the body’s detoxification ability may underlie various chronic neurologic diseases such as Parkinson’s.
Therapeutic considerations to consider when managing the progressive pathology of Parkinson’s Disease, is Nutritional, environmental and Herbal.
Recent clinical research has demonstrated that Blackcurrants can prevent age-related neurodegenerative diseases and improve motor and cognitive functions. The Blackcurrants are also capable of modulating signaling pathways involved in inflammation, cell survival, neurotransmission and enhancing neuroplasticity. The neuroprotective effects of Blackcurrant powder on neurodegenerative diseases are related to phytochemicals such as anthocyanin, caffeic acid, catechin, quercetin, kaempferol and tannin.
A uk study has shown Blackcurrant powder to regulate a family of enzymes called monoamine oxidases, which regulate serotonin and dopamine concentrations in the brain.
These chemicals are known to affect mood and cognition, and are the focus for treatments of both neurodegenerative symptoms associated with Parkinson’s disease and mood disorders, including stress and anxiety.
Given the importance of glutathione as a powerful brain tissue antioxidant, maintaining optimum repletion is recommended. Ongoing supplementation with glutathione can help reduce the damage of Parkinson’s to the heart, liver and muscles.
High dose Vitamin C taken alongside Glutathione, can help conserve glutathione.
Gingko biloba extract exerts profound, widespread tissue effects including membrane stabilizing, antioxidant and free radical scavenging effects. Gingko also enhances the utilization of Oxygen and Glucose. Gingko is also extremely effective inhibitor of lipid peroxidation of cellular membranes, which possesses a protective effect on the neurological system of a Parkinson’s patient.
If you would like to make an appointment to see a Medical Herbalist or Nutritional Therapist, please contact Health Zone Shop and Clinic.
Health Zone Shop and Clinic
30 Wimbledon Hill Road,