Rhinitis is an inflammation of the lining of the nose, characterized by nasal congestion, nasal discharge, sneezing and itching.
Allergic Rhinitis is triggered by inhaled allergens and may be perennial or seasonal (hayfever).
The acute allergic response in rhinitis results from the interaction of an inhaled allergen with a specific IgE antibody on the surface of mast cells and basophils. This leads to the release of histamine and other factors that cause the acute symptoms.
Hypersensitivity begins when IgE antibodies from B lymphocytes are exposed to specific allergens (Pollen). The IgE antibodies then attach to the mast cells in specific locations in the immune system, creating sensitized mast cells.
Mast cells are connective tissue cells that are present in large numbers in the mucosa of the respiratory and digestive tracts. On continual exposure to the same allergen, the allergen attaches to the IgE antibody on the mast cell,stimulating the release of chemical mediators such as histamine from granules within the mast cells. Continue reading ‘Allergic Rhinitis-Hay Fever, symptoms and treatment’ »